The Relationship of Heavy Metals With Lung Cancer: A Systematic Review
Hubungan Logam Berat Dengan Kanker Paru: Sebuah Tinjauan Sistematis
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(1) * Mostafa Salim Mohammed
AL-Najaf Technical Institute, Al-Furat Al-Awsat Technical University, Iraq
Iraq
(*) Corresponding Author
Abstract
General Background: Heavy metals such as lead, cadmium, nickel, and copper are known environmental pollutants with established toxic effects on human health. Specific Background: These elements have been identified as significant contributors to various diseases, with emerging evidence suggesting their role in promoting cancer, particularly lung cancer. Knowledge Gap: Although numerous studies have investigated the relationship between heavy metals and lung cancer, a comprehensive understanding of the impact of various metal concentrations on cancer development and progression remains underexplored. Aims: This systematic review aims to consolidate and analyze the existing literature on the effects of heavy metal exposure on lung cancer, focusing on different biological samples such as plasma, urine, nails, and hair. Results: The review identified consistent evidence linking increased levels of heavy metals with higher risks of lung cancer. Studies highlighted the role of metals like cadmium, chromium, and nickel in not only promoting cancer growth but also in impacting the efficacy of cancer treatment. The findings suggest that exposure to these metals, often from environmental and industrial sources, is a critical risk factor for lung cancer. Novelty: This review uniquely synthesizes data from diverse biological samples, providing a holistic view of how heavy metal exposure influences lung cancer. Implications: The study underscores the importance of monitoring and regulating heavy metal exposure to reduce the incidence of lung cancer. It also emphasizes the need for further research to develop targeted strategies for mitigating the risks associated with heavy metal-induced carcinogenesis.
Highlights:
- Heavy metals like cadmium increase lung cancer risk significantly.
- Diverse samples (plasma, urine) reveal metals' impact on cancer.
- Regulating metal exposure is key to preventing lung cancer.
Keywords: Heavy Metals, Lung Cancer, Cadmium, Carcinogenesis, Toxic Exposure
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References
. A. A. Bhat, E. Moglad, P. Bansal, H. Kaur, M. Deorari, R. Thapa, W. H. Almalki, I. Kazmi, S. I. Alzarea, and N. Kukreti, "Pollutants to Pathogens: The Role of Heavy Metals in Modulating TGF-β Signaling and Lung Cancer Risk," Pathology-Research and Practice, vol. 155260, 2024. DOI: https://doi.org/10.1016/j.prp.2024.155260
. J. P. Chen, L. K. Wang, M.-H. S. Wang, Y.-T. Hung, and N. K. Shammas, Remediation of Heavy Metals in the Environment. CRC Press, 2016. DOI: https://doi.org/10.1201/9781315374536
. I. Cimboláková, I. Uher, K. V. Laktičová, M. Vargová, T. Kimáková, and I. Papajová, "Heavy Metals and the Environment," Environmental Factors Affecting Human Health, vol. 1, p. 29, 2019. DOI: https://doi.org/10.5772/intechopen.86876
. H. Tang, G. Xiang, W. Xiao, Z. Yang, and B. Zhao, "Microbial Mediated Remediation of Heavy Metals Toxicity: Mechanisms and Future Prospects," Frontiers in Plant Science, vol. 15, p. 1420408, 2024. DOI: https://doi.org/10.3389/fpls.2024.1420408
. A. B. Fulke, S. Ratanpal, and S. Sonker, "Understanding Heavy Metal Toxicity: Implications on Human Health, Marine Ecosystems and Bioremediation Strategies," Marine Pollution Bulletin, vol. 206, p. 116707, 2024. DOI: https://doi.org/10.1016/j.marpolbul.2024.116707
. R. Ghosh, "Heavy Metal Accumulation in Human Body: A Molecular Toxicity Leading to Cancer," 2024. DOI: https://doi.org/10.21275/SR24202163057
. H. S. Budi, M. J. Catalan Opulencia, A. Afra, W. K. Abdelbasset, D. Abdullaev, A. Majdi, M. Taherian, H. A. Ekrami, and M. J. Mohammadi, "Source, Toxicity and Carcinogenic Health Risk Assessment of Heavy Metals," Reviews on Environmental Health, vol. 39, no. 1, pp. 77-90, 2024. DOI: https://doi.org/10.1515/reveh-2022-0096
. R. Teschke, "Copper, Iron, Cadmium, and Arsenic, All Generated in the Universe: Elucidating Their Environmental Impact Risk on Human Health Including Clinical Liver Injury," International Journal of Molecular Sciences, vol. 25, no. 12, p. 6662, 2024. DOI: https://doi.org/10.3390/ijms25126662
. N. Ahmad, S. N. A. Bukhari, M. A. Hussain, H. Ejaz, M. U. Munir, and M. W. Amjad, "Nanoparticles Incorporated Hydrogels for Delivery of Antimicrobial Agents: Developments and Trends," RSC Advances, vol. 14, no. 19, pp. 13535-13564, 2024. DOI: https://doi.org/10.1039/D4RA00631C
. N. Marufi, G. O. Conti, P. Ahmadinejad, M. Ferrante, and A. A. Mohammadi, "Carcinogenic and Non-Carcinogenic Human Health Risk Assessments of Heavy Metals Contamination in Drinking Water Supplies in Iran: A Systematic Review," Reviews on Environmental Health, vol. 39, no. 1, pp. 91-100, 2024. DOI: https://doi.org/10.1515/reveh-2022-0060
. H.-H. Huang, J.-Y. Huang, C.-C. Lung, C.-L. Wu, C.-C. Ho, Y.-H. Sun, P.-C. Ko, S.-Y. Su, S.-C. Chen, and Y.-P. Liaw, "Cell-Type Specificity of Lung Cancer Associated with Low-Dose Soil Heavy Metal Contamination in Taiwan: An Ecological Study," BMC Public Health, vol. 13, pp. 1-12, 2013. DOI: https://doi.org/10.1186/1471-2458-13-330
. N.-W. Lee, H.-Y. Wang, C.-L. Du, T.-H. Yuan, C.-Y. Chen, C.-J. Yu, and C.-C. Chan, "Air-Polluted Environmental Heavy Metal Exposure Increase Lung Cancer Incidence and Mortality: A Population-Based Longitudinal Cohort Study," Science of The Total Environment, vol. 810, p. 152186, 2022. DOI: https://doi.org/10.1016/j.scitotenv.2021.152186
. S. Pietrzak, J. Wójcik, P. Baszuk, W. Marciniak, M. Wojtyś, T. Dębniak, C. Cybulski, J. Gronwald, J. Alchimowicz, and B. Masojć, "Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer," Biomolecules, vol. 11, no. 8, p. 1160, 2021. DOI: https://doi.org/10.3390/biom11081160
. M. Scimeca, A. Orlandi, I. Terrenato, S. Bischetti, and E. Bonanno, "Assessment of Metal Contaminants in Non-Small Cell Lung Cancer by EDX Microanalysis," European Journal of Histochemistry: EJH, vol. 58, no. 3, 2014. DOI: https://doi.org/10.4081/ejh.2014.2403
. K. Zhang, T. Zhu, X. Quan, Y. Qian, Y. Liu, J. Zhang, H. Zhang, H. Li, and B. Qian, "Association Between Blood Heavy Metals and Lung Cancer Risk: A Case-Control Study in China," Chemosphere, vol. 343, p. 140200, 2023. DOI: https://doi.org/10.1016/j.chemosphere.2023.140200
Copyright (c) 2024 Mostafa Salim Mohammed
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